EIF3A

Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa

Identifiers

EIF3S10; EIF3A; EIF3; KIAA0139; P167; eIF3-p170; eIF3-theta; p180; p185

External IDs

OMIM: 602039 MGI: 95301 HomoloGene: 2779 GeneCards: EIF3S10 Gene

Gene Ontology
Molecular function	• translation initiation factor activity • structural molecule activity
Cellular component	• cytoplasm • eukaryotic translation initiation factor 3 complex
Biological process	• translation • regulation of translational initiation • biological_process
Sources: Amigo / EGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
120.78 - 120.83 Mb

Chr 19:
60.82 - 60.85 Mb

PubMed search

[1]

[2]

Eukaryotic translation initiation factor 3 subunit A is a protein that in humans is encoded by the EIF3A gene.^[1]^[2]^[3]

Interactions

EIF3A has been shown to interact with EIF3EIP,^[4]^[5] EIF4B,^[6] DISC1,^[7] FBXO32,^[8] EIF3D,^[4]^[9]^[10] EIF3C,^[9]^[10] EIF4G2,^[11]^[12] EIF3B,^[9]^[13]^[10]^[14] EIF3J,^[9]^[10] EIF3S6,^[4]^[9]^[5] EIF3F,^[4]^[9]^[10] EIF3G,^[9]^[10] EIF3H,^[4]^[9]^[10] EIF3I^[4]^[9]^[15] and EIF3K.^[4]^[9]

References

^ Johnson KR, Merrick WC, Zoll WL, Zhu Y (Apr 1997). "Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae". J Biol Chem 272 (11): 7106–13. doi:10.1074/jbc.272.11.7106. PMID 9054404.
^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ "Entrez Gene: EIF3S10 eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8661.
^ ^a ^b ^c ^d ^e ^f ^g Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.
^ ^a ^b Morris-Desbois, C; Réty S, Ferro M, Garin J, Jalinot P (Dec. 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. (United States) 276 (49): 45988–95. doi:10.1074/jbc.M104966200. ISSN 0021-9258. PMID 11590142.
^ Méthot, N; Song M S, Sonenberg N (Oct. 1996). "A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5328–34. ISSN 0270-7306. PMID 8816444.
^ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986.
^ Lagirand-Cantaloube, Julie; Offner Nicolas, Csibi Alfredo, Leibovitch Marie P, Batonnet-Pichon Sabrina, Tintignac Lionel A, Segura Carlos T, Leibovitch Serge A (Apr. 2008). "The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy". EMBO J. (England) 27 (8): 1266–76. doi:10.1038/emboj.2008.52. PMID 18354498.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Mayeur, Greg L; Fraser Christopher S, Peiretti Franck, Block Karen L, Hershey John W B (Oct. 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. (Germany) 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. ISSN 0014-2956. PMID 14519125.
^ ^a ^b ^c ^d ^e ^f ^g Block, K L; Vornlocher H P, Hershey J W (Nov. 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. ISSN 0021-9258. PMID 9822659.
^ Gradi, A; Imataka H, Svitkin Y V, Rom E, Raught B, Morino S, Sonenberg N (Jan. 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. (UNITED STATES) 18 (1): 334–42. ISSN 0270-7306. PMID 9418880.
^ Henis-Korenblit, S; Strumpf N L, Goldstaub D, Kimchi A (Jan. 2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation". Mol. Cell. Biol. (UNITED STATES) 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. ISSN 0270-7306. PMID 10611228.
^ Harris, Thurl E; Chi An, Shabanowitz Jeffrey, Hunt Donald F, Rhoads Robert E, Lawrence John C (Apr. 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMID 16541103.
^ Méthot, N; Rom E, Olsen H, Sonenberg N (Jan. 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. (UNITED STATES) 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. ISSN 0021-9258. PMID 8995410.
^ Asano, K; Kinzy T G, Merrick W C, Hershey J W (Jan. 1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. ISSN 0021-9258. PMID 8995409.

Dong Z, Zhang JT (2006). "Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer.". Crit. Rev. Oncol. Hematol. 59 (3): 169–80. doi:10.1016/j.critrevonc.2006.03.005. PMID 16829125.
Kanner SB, Reynolds AB, Vines RR, Parsons JT (1990). "Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3328–32. doi:10.1073/pnas.87.9.3328. PMID 2110361.
Méthot N, Song MS, Sonenberg N (1996). "A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.". Mol. Cell. Biol. 16 (10): 5328–34. PMID 8816444.
Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3.". J. Biol. Chem. 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. PMID 8995409.
Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
Scholler JK, Kanner SB (1997). "The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex.". DNA Cell Biol. 16 (4): 515–31. doi:10.1089/dna.1997.16.515. PMID 9150439.
Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334–42. PMID 9418880.
Zhang Y, LeRoy G, Seelig HP, et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.". Cell 95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534.
Tong JK, Hassig CA, Schnitzler GR, et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.". Nature 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.
Ensinger C, Obrist P, Mikuz G, et al. (1999). "Assignment1 of the p150 subunit of the eukaryotic initiation factor 3A gene (EIF3A) to human chromosome band 10q26 by in situ hybridisation.". Cytogenet. Cell Genet. 83 (1-2): 74–5. doi:10.1159/000015130. PMID 9925932.
Zhang Y, Ng HH, Erdjument-Bromage H, et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.". Genes Dev. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMID 10444591.
Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.". Mol. Cell. Biol. 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. PMID 10611228.
Humphrey GW, Wang Y, Russanova VR, et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.
Lin L, Holbro T, Alonso G, et al. (2001). "Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.". J. Cell. Biochem. 80 (4): 483–90. doi:10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B. PMID 11169732.
Pincheira R, Chen Q, Zhang JT (2001). "Identification of a 170-kDa protein over-expressed in lung cancers.". Br. J. Cancer 84 (11): 1520–7. doi:10.1054/bjoc.2001.1828. PMID 11384103.
Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.". J. Biol. Chem. 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3

Archaeal	aIF1 · aIF2 · aIF5 · aIF6

Eukaryotic	eIF1 (AX, AY, 1B) eIF2 (α, β, γ) eIF3 (A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (A, A2, B) eIF6

Elongation factor

Prokaryotic (EF-Tu, EF-Ts, EF-G) · Archaeal (aEF-1, aEF-2) · Eukaryotic (EEF-1, EEF-2)

Release factor

Prokaryotic · Archaeal · Eukaryotic

Other

RPS1 · RPS2 · RPS3 · RPS4 · RPS5 · RPS6 · RPS7 · RPS8 · RPS9 · RPS10 · RPS11 · RPS12 · RPS13 · RPS14 · RPS15 · RPS16 · RPS17 · RPS18 · RPS19 · RPS20 · RPS21 · RPS22 · RPS23 · RPS24 · RPS25 · RPS26 · RPS27 · RPS28 · RPS29

Other concepts

Aminoacyl tRNA synthetase · Reading frame · Start codon · Shine-Dalgarno sequence/Kozak consensus sequence

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EIF3A

Interactions

References

Further reading