Minutes of Meeting
Minutes of Meeting

Inorganic_pyrophosphatase

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pyrophosphatase (inorganic) 1
Identifiers
Symbol PPA1
Alt. symbols PP
Entrez 5464
HUGO 9226
OMIM 179030
RefSeq NM_021129
UniProt Q15181
Other data
EC number 3.6.1.1
Locus Chr. 10 q11.1-q24
pyrophosphatase (inorganic) 2
Identifiers
Symbol PPA2
Entrez 27068
HUGO 28883
OMIM 609988
RefSeq NM_176869
UniProt Q9H2U2
Other data
Locus Chr. 4 q25

Pyrophosphatase (or inorganic pyrophosphatase) is an enzyme that converts one molecule of pyrophosphate to two phosphate ions. This highly exergonic reaction (about −34KJ change in free energy) can be coupled to unfavorable biochemical transformations in order to drive these transformations to completion, as in lipid synthesis and other biochemical transformations.

Thermostable pyrophosphatase has been isolated from the extremophile Thermococcus litoralis.

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